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However, this stimulant effect is also why phentermine is strictly a short-term solution

[DOI] [PubMed] [Google Scholar] 141.L F, Jin T, Drucker DJ

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Furthermore, the cardiovascular benefits emerged early in treatment, preceding significant weight loss, suggesting that the cardiovascular effects may be mediated, at least partially, by other salutary processes in atherosclerotic protection

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[35] The pharmacological effects that make these medications effective for diabetes and weight loss may influence digestive physiology in ways that could affect gallbladder function