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And then there are some more serious reported side effects as well

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A recent propensity-matched cohort study also identified obesity as a risk factor for corticosteroid use, therapy escalation, and colectomy in UC patients (85)

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Therefore, by integrating both direct and indirect evidence, we conducted a systematic review and NMA to compare the efficacy and tolerability of different GLP-1RAs and to contrast them with traditional antidiabetic drugs, thereby offering valuable guidance for clinical treatment