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This group of PIONEER studies was important in demonstrating that oral SMG is effective for controlling glycemia and reducing weight in patients with DM2 [68,76,78,79,80,81,82,83] and as a non-inferior option compared to injectables for glycemic control [84,85,86]

doi:10.1152/ajpregu.00449.2010 174

10.1007/s00125-008-1195-5

About 75% of her patients improve, and nearly half have complete resolution of their orthostatic intolerance, often with dramatic improvements in pelvic pain and interstitial cystitis-type symptoms

Am J Hum Genet 1989