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But what I think is missing from the conversation is the side effects. These are common and unpleasant

And I've said that on this show many, many times

American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement on the Association of Sglt-2 Inhibitors and Diabetic Ketoacidosis

RESULTS: Overall GI adverse events were 1.86 times higher with *both* agents (95% CI=1.56, 2.21), with tirzepatide showing a greater risk (RR 2.94, 95% CI=2.61, 3.32) than semaglutide (RR 1.68, 95% CI=1.46, 1.94)

Evening dosing can also help some patients sleep through mild digestive discomfort , which may be easier to manage during the night