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Description
While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

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Unlike Rybelsus, which was the first oral GLP-1 medication but still a peptide, orforglipron is the first non-peptide oral GLP-1 receptor agonist
How GLP-1 Receptor Agonists Could Complement MASH Treatment

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