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Project Number: 20-021 (to LH)

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Dietary modifications: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods, particularly during dose escalation Reduce alcohol intake, which can independently irritate the gastrointestinal tract Stay well hydrated, especially if experiencing loose stools Lifestyle adjustments: Avoid lying down immediately after eating Allow adequate time between meals to support gastric emptying Medication timing: Some individuals find that choosing an injection day when dietary intake can be more easily managed helps reduce the impact of acute gastrointestinal symptoms

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