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doi: 10.1016/j.isci.2024.109903

Someone who slowly adds 20 pounds by their fifties, or gains weight after menopause as part of expected physiological change, may be on a very different footing from someone who has carried the disease since childhood

It was designed as a safety valve for exceptional circumstances

Gut 69(12):22322243 Herath M, Hosie S, Bornstein JC, Franks AE, Hill-Yardin EL (2020) The role of the gastrointestinal mucus system in intestinal homeostasis: implications for neurological disorders

Consider adding: Strength training two to three times per week Daily walking (target 7,000 to 10,000 steps) Low-impact cardio or short interval sessions Consistency matters more than intensity when it comes to long-term success

This peptide, produced by enteroendocrine cells in response to nutrient intake, plays a central role in regulating appetite, insulin secretion, and glucose metabolism