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Adding a third target changes the mechanism

GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors

Bridwell, GLP-1 agonists: A review for emergency clinicians, The American Journal of Emergency Medicine, Volume 78, 2024, Pages 89-94, ISSN 0735-6757, Chavda, V

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That means improving access, preparing patients for side effects, supporting adherence, using digital follow-up, involving pharmacists and care teams, and creating a more compassionate long-term conversation about weight, health, and quality of life

Circulation 123(18):20152019