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Therefore, in patients receiving GLP-1-based therapies, considering possible statistically significant reduction in muscle tissue, it would seem highly advisable to implement targeted physical exercise to preserve and potentially enhance muscle mass [47,167]

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In contrast those losing weight through diet and exercise alone only saw a reduction of 3% over that time period, the same study found

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1 While this is highly effective for weight management, it leads to a significantly reduced calorie intake