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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this Article

Single-cell and multi-cell cultures can both form hepatic spheroids

Reducing alcohol and caffeine intake is advisable, as both can contribute to dehydration and blood pressure fluctuations

Proportion of Participants Losing 5% Fasting Body Weight at 12 Weeks of Full Therapeutic Dose In all populations, semaglutide 2.4 mg was associated with a higher likelihood of participants losing 5% of baseline fasting body weight at 12 weeks versus all available comparators (liraglutide 3.0 mg and orlistat 120 mg)

No, sulfonylureas (such as gliclazide) are chemically distinct from sulfonamide antibiotics despite similar-sounding names

However, some people continue experiencing mild intermittent nausea, particularly if they eat too much at once or consume rich foods