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[DOI] [PubMed] [Google Scholar] 95.Fildes A, van Jaarsveld CH, Llewellyn CH, Fisher A, Cooke L, Wardle J

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We hypothesized that a positive allosteric modulator (PAM) could be used as a tool to lower this activation barrier, thereby increasing assay sensitivity and facilitating the detection of weak agonists in a cell-based functional assay