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Nevertheless, the alterations in the gut microbiota of diabetic individuals by metformin treatment show consistent results in certain bacteria, in both humans and rodents

One current example of polypharmacology in the clinic is Eli Lillys investigational drug Retatrutide, which acts as a triple agonist against glucagon, GIP, and GLP-1 receptors (Figure 1), engendering even greater weight loss in clinical trials than approved blockbuster drugs Semaglutide (GLP1-R agonist) and Tirzepatide (dual GLP1-R/GIP agonist)

The rationale is smoother blood levels, fewer GI side effects from peak concentrations, and more consistent appetite suppression throughout the week

GLP-1 Recomposition Semaglutide The foundational GLP-1 physician-directed, paired with muscle-protective peptides

It wasnt common for me to take patients who were unresponsive to the most aggressive weight loss therapies (including bariatric surgery), put them on these medications, and watch them lose weight

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