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How postpartum thyroiditis could silently wreak havoc on your healthand what you can do about it now

In hEDS-associated neuropathic POTS where partial sympathetic denervation of the lower extremity vasculature produces blunted vasoconstriction, blood already pools in peripheral capacitance vessels on standing, stroke volume is structurally reduced, and the sympathetic nervous system is already operating near its compensation ceiling the additional vasodilatory and chronotropic load imposed by chronic dual incretin receptor agonism may have limited physiological reserve to absorb it

In an animal model of depression and diabetes, however, exendin-4 led to antidepressant-like effects, which was associated with changes in microglial function 168

Once the medication is discontinued, some of those appetite signals may gradually return

Clinical trials in people with type 2 diabetes and CKD have shown potential kidney benefits with semaglutide, though this is not a licensed renal indication in the UK