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Understanding the Risks and Making Informed Choices What We Know for Sure Research clearly shows: GLP-1 medications should not be used during pregnancy A 2-month washout period is necessary before conceiving Accidental early exposure doesnt automatically mean harm Animal studies show potential risks to developing babies Human data is limited but somewhat reassuring What We Dont Know Yet We still need more research on: Long-term effects on babies exposed during pregnancy Whether different GLP-1 drugs have different risk levels Impact on babies when used in the second and third trimesters Effects on breastfeeding and breast milk Making Your Decision Talk openly with your healthcare team about: Your weight loss goals Your pregnancy timeline Your overall health needs Your risk factors Your emotional readiness Together, you can create a plan that protects your health and your future baby

Currently, there is one molecularly defined receptor for GLP1 (Thorens, 1992), and this receptor is expressed throughout the body in most major organ systems, including the digestive and cardiovascular systems, as well as the peripheral and central nervous systems (Baggio et al., 2018

The two brands differ in FDA-approved indication only: Zepbound is approved for chronic weight management and sleep apnea in obesity, while Mounjaro is approved for type 2 diabetes

Rammohan A, Bhaskar BV, Venkateswarlu N, Gu W, Zyryanov GV

The integration of gustatory sensory signals occurs primarily in the orbitofrontal, prefrontal, and insular cortex (110)

A service evaluation exploring the effectiveness of a locally commissioned tier 3 weight management programme offering face-to-face, telephone and digital dietetic support