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Common adverse events of GLP-1RAs include nausea, vomiting, diarrhea, and constipation, with a significantly higher incidence of nausea than that of placebo [47] [48]

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Progesterone provides the necessary counterbalance, protecting the uterine lining while estrogen exerts its broader systemic effects

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In this context, therapies such as GLP-1RAs may represent a complementary strategy aimed at modulating both metabolic dysfunction and inflammation, thereby optimizing disease control and improving long-term outcomes in PsA