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Major weight loss most likely will not occur in the first week of treatment with a GLP-1

doi: 10.1001/jamainternmed.2018.2933 [DOI] [PMC free article] [PubMed] [Google Scholar] 134

Broadly, GLP-1RAs act to increase insulin secretion, decrease glucagon secretion, delay gastric emptying, and induce satiety [14, 19]
It has not been studied in people who have a stomach problem that causes slow emptying (gastroparesis) and is not for people with slow emptying of the stomach