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While it was initially reported that mice deficient in Insl5 were mildly glucose-intolerant (170), this appears to be age (170) and strain-dependent (164, 168)

In fact, the omitted study was a pooled analysis of 5 RCTs 196,197,198,199,200 of 5,325 patients with obesity followed for up to 3 years, which had shown that liraglutide was no different from placebo for depressive symptoms as scored on the Patient Health Questionnaire-9, while also highlighting a small increased risk of suicidal behavior 193

No increase in dose-dependent gastrointestinal adverse events was observed

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Kirkegrd, J., Mortensen, F