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People with Type 2 diabetes might not produce enough GLP-1, or its effects might be too weak

Notably, these pooled analyses included limited patients treated with semaglutide or tirzepatide

Protect against heart failure

adults (~32 million people) have taken GLP-1 medications ( [1] ), and roughly 4% of all Americans (~13 million) were on a GLP-1 drug in 2024 ( [2] )

Yang, Y., et al

Furthermore, the risks of myocardial infarction (HR 0.91, 95% CI 0.840.98 with GLP-1RAs and HR 0.89, 95% CI 0.800.98 with SGLT2is) and cardiovascular death (HR 0.88, 95% CI 0.800.96 with GLP-1RAs and HR 0.84, 95% CI 0.750.94 with SGLT2is) were similarly reduced in both GLP-1RA and SGLT2i groups, while the risk of stroke was reduced only with GLP-1RAs (HR 0.86, 95% CI 0.770.97 with GLP-1RAs and HR 0.97, 95% CI 0.861.10 with SGLT2is)