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Her grandmother died of complications from RA, and in the last few months of her life, it was Smith who served as her caregiver, administering doses of methotrexate to treat her pain and inflammation

Journal of Biological Chemistry 272 , 2264222647, doi:10.1074/jbc.272.36.22642 (1997)

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Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity