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When the body experiences significant caloric restriction or rapid fat loss, it may interpret this as a period of nutritional stress, potentially affecting the hypothalamic-pituitary-ovarian axis
In alignment with American College of Rheumatology and American College of Physicians guidelines, first-line management for osteoarthritis includes exercise and weight loss

This means more snacking, more frequency, and more indulgence

Weintraub M, Sundaresan PR, Schuster B, Averbuch M, Stein EC, Byrne L

For other types of ligands, e.g

Nutritional Strategies for Hair Health A balanced diet remains fundamental to prevent hair loss during weight reduction
