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Another phase 2b study in patients with NASH with cirrhosis and severe portal hypertension is assessing the efficacy of three doses Emricasan (10, 50, 100 mg/day) on portal hypertension (ENCORE-PH, NCT02960204)

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The lower esophageal sphincter (LES) is a muscular valve located at the top of the stomach that opens to let food enter, and then closes to keep the digestive acids and food in the stomach