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While the intestinal changes observed with cold stress were maintained in DIRKO mice, GLPDRKO mice failed to increase jejunal villi length and crypt depth, indicating that, in the context of GLP-1R deficiency, GLP-2R action was required for this adaptation

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2 Metformin (MET) is recommended as the first-line treatment for patients with T2DM due to well-established efficacy, safety, low cost, and data demonstrating a reduction in risk of cardiovascular (CV) events

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