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After your last injection: After 1 week: approximately 50% of the last dose remains active After 2 weeks: approximately 25% remains After 3 weeks: approximately 12.5% remains After 4 to 5 weeks: the drug has cleared to clinically negligible levels This exponential decay is why most physicians choose a minimum 1-week gap

The combination of protein adequacy, fasting-induced metabolic signaling, and resistance exercise provides the strongest protection against lean mass loss

This deceleration is normal

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Frequently Asked Questions How long does it usually take for semaglutide to stop being effective

This cumulative approach ensures you get the best possible outcome that looks natural and lasts