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Material and methods Contractile studies on human cardiac preparations In brief, human atrial preparations obtained during the cardiac surgery at the sites where extracorporeal circulation needles were inserted into the right atrial appendage and were rapidly (within 30 min) transferred into the laboratory in flasks filled with a modified Tyrodes solution

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In standard functional assays, orforglipron shows greater than 100-fold selectivity for the GLP-1 receptor over the glucagon receptor, the GIP receptor, and the secretin receptor

Cannon, H

Resources on muscle loss during GLP-1 therapy provide additional context for those concerned about this issue