how does glp-1 work in the brain Ultimate Guide to GLP-1: Basics, Benefits, and More Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)
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doi: 10.3389/fonc.2025.1498927

This increased cAMP activates PKA which in turn promotes insulin synthesis and secretion and inhibits glucagon release (Yang and Yang, 2016)
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These medications appear to affect brain pathways involved in reward and craving, which could help explain the lower rates of substance use disorders observed in our study. The researchers said the findings do not establish cause and effect and cautioned against prescribing the medications for addiction treatment without further study
