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Tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis, as further slowing of gastric emptying could exacerbate symptoms

Phentermine is limited to 12-week courses and is considered first-line pharmacotherapy under the step therapy protocol

Today they are also widely prescribed for weight loss because they regulate appetite, insulin levels, and blood sugar

3.67 times higher risk of gastroparesis , limiting the passage of food from the stomach to the small intestine and results in symptoms like vomiting, nausea and abdominal pain
5B) could be an interference of GLP-1RA treatment with the interdigestive migrating motor complex (MMC), particularly phase 3 of this complex, which is composed of pressure waves often originating in the stomach and propagated segment by segment toward the duodenum and jejunum (108), which is thought to clear the remnants of the preceding meal including indigestible gastric content from the stomach (108, 109)
