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Cardiometabolic Markers (Phase 2) Systolic blood pressure: reduced by 48 mmHg across dose groups Fasting triglycerides: reduced by up to 30% in higher dose cohorts HbA1c: significant reductions in subjects with elevated baseline glucose Waist circumference: significant reductions correlated with visceral fat loss Common Side Effects Observed in Retatrutide Research Consistent with other GLP-1 class compounds, the most commonly observed adverse events in retatrutide clinical research include: The addition of GIP agonism in retatrutide appears to reduce the severity of nausea compared to GLP-1-only compounds at equivalent efficacy a finding that distinguishes it from semaglutide

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Administered as a once-weekly injection or once-daily oral tablet, it is recommended that GLP-1s be used in conjunction with a balanced diet and exercise

Journal of Obesity & Metabolic Syndrome, 27 (1), 424

These figures come from a single 24-week phase 2 trial

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