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The accumulated evidence from CVOTs has not only informed clinical practice guidelines but has also empowered healthcare providers with a valuable therapeutic option for T2D patients who have high cardiovascular risk

In type 2 diabetes rat models, where bone mass is often reduced, contrary to humans, where bone mass is often normal or increased, liraglutide administration in the range of ~ 110160 nmol/kg/day resulted in increased trabecular BMD and restoration of trabecular microarchitecture parameters in the appendicular and axial skeleton [6367]

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(28) The crude incidence rates of LLA were 6.1 per 10,000 person-years for GLP-1 receptor agonists, 1.5 for SGLT-2 inhibitors, 4.6 for DPP-4 inhibitors, and 1.9 for older agents

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At least 10 generics firms have approached Indias drug regulator for permission to conduct human clinical trials on semaglutide, according to a report by Arias and his team at Iqvia