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Evidence for separate roles Several lines of evidence support the notion of distinct roles for peripheral and central GLP-1 in appetite regulation: Differential breakdown: Peripheral GLP-1 has a very short half-life in the blood (around two minutes) due to enzymatic degradation

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Available: [8] C

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eClinicalMedicine 58 , 101962 (2023)

The GIP component may also contribute to potentially milder gastrointestinal side effects compared to GLP-1-only medications