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As for internalization, biased signaling was highly predictive of maximal agonist-induced insulin release, with compounds biased away from -arrestin-2 recruitment the most effective (Fig
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Do not guess

2025 Dec;222:108045

Theyre very close

A retrospective analysis indicated GLP-1RA use was associated with reduced MS incidence (138), and a small study of dulaglutide in 13 patients demonstrated preserved endothelial function over 12 months (183)

This makes sense because the drugs work by modulating gut function
