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GLP-1 stimulation induced serine phosphorylation of wild-type GLP-1R, which was abolished in all individual doublet as well as triple doublet phospho-null mutants
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Compared with liraglutide alone, the combined treatment decreased time to complete a stair climb test by 1.2 s [95% confidence interval 0.61.9] (corresponding to 8.6%) and improved peak oxygen consumption by 3.0 mL/min/kg fat-free mass [95% confidence interval 0.55.5]
