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Empower Pharmacy offers tirzepatide-niacinamide in concentrations of 8 mg/mL or 17 mg/mL tirzepatide combined with 2 mg/mL niacinamide

formal analysis and writingoriginal draft: S.J.M

Clinical trials show that patients losing 10-15% of body weight often experience natural decreases in blood pressure, sometimes requiring medication adjustments

Major cardiovascular outcome trials include: LEADER trial (liraglutide): Demonstrated a significant reduction in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and high cardiovascular risk SUSTAIN-6 (semaglutide): Showed reduced cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke REWIND (dulaglutide): Confirmed cardiovascular benefits across a broad patient population SELECT trial (semaglutide): Showed reduced MACE in people with obesity without diabetes, though this evidence is not yet fully incorporated into UK labelling [17] These trials consistently found that the modest heart rate increases observed did not translate into adverse cardiovascular outcomes

Diabetic Ketoacidosis and Ketosis: In individuals with T1DM, GLP-1 RAs were associated with an increased risk of ketosis, including diabetic ketoacidosis (DKA) (Class IV