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A 2024 pooled analysis of the SURMOUNT trials (Aronne et al., Lancet ) found that 4.3% of patients discontinued tirzepatide due to GI side effects

The rush to reach maximum doses provides little benefit compared to tolerating lower doses comfortably for longer periods
Increased risk of type 2 diabetes in Alzheimer disease

The popularity of the drug has been driven by social media influencers, celebrities and other high-profile people and have led to the demand for off-label use of these products for weight loss

The water-resistant construction helps maintain comfort throughout the day without interfering with your normal activities
