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While incretins are effective for weight management, they often cause nausea, vomiting and other gastrointestinal issues, as well as other tolerability and safety concerns

When muscle mass decreases, bones may receive less mechanical stimulation, which can contribute to reduced density

Diabetes Res Clin Pract 2012;98(2):271284

But scientists quickly realized these medications were doing more than slowing digestion or curbing appetite

Quick Answer: GLP-1 receptor agonists produce significant reductions in abdominal fat and waist circumference as part of generalized weight loss, though they do not selectively target belly fat

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