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Insulin syringe reference (U-100): 1 IU = 50 mcg 100 mcg = 2 IU (0.02 mL) 500 mcg = 10 IU (0.1 mL) 1,000 mcg = 20 IU (0.2 mL) Typical research scheduling: Once weekly subcutaneous administration is commonly studied

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Patients May Have the Best Results Staying on These Medications The trials specifically looked at weight loss results, but doctors say the findings suggest that staying on a maintenance dose of medication can support improvements in heart health and blood sugar management
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ClinicalTrials.gov entries (e.g., NCT05931367 for TRIUMPH-4)

Treating insulin resistance with metformin as a strategy to improve clinical outcomes in treatment-resistant bipolar depression (the TRIO-BD Study): a randomized, quadruple-masked, placebo-controlled clinical trial
