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In another study, GLP-1 and exendin-4 treatment was shown to normalize the altered vascular tone in type 2 diabetic rats, with the latter being less effective [115]

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Current best practice suggests Retatrutide could reduce diabetes medication burden rather than serve as a complete Metformin substitute

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Patients undergoing GLP-1 RA therapy who adopt unstructured reductions in dietary intake should be closely monitored for gut microbiome dysbiosis, as preservation of gut microbiome eubiosis is foundational to health