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Materials and methods The effects of long-term exposures to tirzepatide, a novel dual GIP/GLP-1 receptor agonist, on neurotoxicity and behavioral changes in the D-galactose/aluminium chloride (D-gal/AlCl3)-induced rats' AD-like pathological model were evaluated

He underwent a 27 day inpatient fast with weekly tirzepatide, including 21 day water fast with structured refeeding