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Two patients losing the same percentage of body weight may have very different risk profiles: Risk is behavioural, not automatic

51 Gallbladder Disease Rapid weight loss can increase the risk of cholelithiasis and cholecystitis, and was observed in major GLP-1RA trials

While Semaglutide predominantly increases insulin secretion and decreases hunger, tirzepatide targets numerous pathways for a more complete strategy, which frequently results in more weight reduction and better metabolic outcomes

patients in pill form, expanding access to clinically proven weight-loss and cardiovascular risk-reduction therapy with broad affordability options

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GLP-1 receptor agonists have well-characterized safety profiles based on extensive use in diabetes and obesity management, but specific considerations apply when considering their use in patients with substance use disorders