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In accordance with the target trial emulation framework, we first specified the protocol of a hypothetical randomized controlled trial (RCT) comparing the effects of initiating a GLP-1RA versus an SGLT2 inhibitor on the outcomes of AF/Aflutter and stroke among patients with T2D who have been receiving stable dose of levothyroxine

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However, recent patient reports and clinical observations suggest a potential link between GLP-1 therapy and depression or emotional flattening, prompting important conversations about mental health screening before starting treatment

The plan might include gradually de-escalating the medication dose, considering alternative medications, intensified lifestyle support and more frequent check-ins

The Sema/Cag Blend is engineered for researchers studying the intersection of incretin hormones and amylin analogues

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