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Reduction in nonfatal MI was noted only with SGLT2i but the effect was modest (10% relative risk reduction)

Upon ADA binding, activation of plasminogen-2 occurs, which raises plasmin levels

Monitor blood sugars closely after initiation and adjust medications as needed

73,74 The anti-fibrotic effects of DPP4 inhibitors such as vildagliptin and sitagliptin have been demonstrated in a mouse model of bleomycin-induced skin fibrosis, characterized by improved dermal texture, reduced hydroxyproline content, and decreased myofibroblast deposition through the inhibition of TGF--induced ERK signaling

Stay at the current dose for one to two additional weeks

Improved Insulin Sensitivity : These medications help increase insulin sensitivity, which can reduce fat storage in the liver and improve metabolic function