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Jamie Bennett, a spokesperson for Wegovy and Ozempic maker Novo Nordisk, declined to comment on the concept of deprescription, noting that its drugs are intended for chronic conditions

Glucagon-like peptide-1 in the rat brain: distribution of expression and functional implication
If you have a history of UTIs, this distinction is clinically significant

However, because of their lesser magnitude of glucose lowering, they are prescribed more commonly as an addition to another type of medicine rather than as monotherapy: Metformin: First-line therapy that decreases hepatic glucose output

Despite comprehensive propensity matching, unmeasured confounders, including lifestyle factors and medication adherence, could influence results

Step-therapy mandates that patients fail metformin or orlistat add 36 months to initiation timelines, increasing dropout risk
