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Protocols typically involve 10 to 40% reductions in total energy intake compared to ad libitum-fed controls, but with adequate nutrition and a controlled physical environment (2)

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Overall, these results suggests that lethal IB-DNQ treatment conditions as a single agent or in combination with Rucaparib inhibition significantly alter H2AX thermal stability

The latter is believed to be a key regulating factor of several essential metabolic pathways, acting through sulfhydryl-disulfide exchange reactions between sulfhydryl groups of the enzymes and the oxidized form, cystamine

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Further investigation is required to study if this compound could be a potential new anti c-Met drug candidate