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When your gut bacteria consume these fibers, they produce short-chain fatty acids like butyrate, which also trigger the release of GLP-1

doi: 10.1016/0026-0495(78)90045-8

The muscle loss conversation around GLP-1sand now triple agonists like retatrutideneeds more clinical context

While this fatigue can be frustrating, the good news is that its usually manageable and often temporary

If your body reacts poorly, if your dose shouldn't rise yet, or if another treatment makes more sense, a clinician can act on that information

if more than 3 days, skip that dose Daily GLP-1s: If you miss a dose, follow your PIL instructions If you take insulin or sulfonylureas alongside GLP-1 medications, do not adjust these doses yourself without medical advice, as this could increase hypoglycaemia risk Report persistent side effects to your GP rather than stopping treatment abruptly Some patients may require dose adjustment if they develop acute illness, undergo surgery, or experience significant changes in kidney function