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How These Drugs Actually Work and Why Stopping Is Complicated Weight regulation is not a matter of willpower

P38 MAPK, p38 Mitogen-Activated Protein Kinase

doi: 10.3389/fendo.2017.00047 123 GibbsJYoungRCSmithGP

We still have yet to learn how long weight loss may last, but clinical trials demonstrate that there is sustainable weight loss even after stopping the medication

In recent years, extensive literature has reported that a variety of signaling pathways and transcription factors are involved in the fat differentiation process of WAT, such as the NOS pathway, neuropeptide S [87] pathway, SIRT1 [88] pathway, STAT3 [89], bone morphogenetic protein 4 (BMP4) [90] pathway, etc

Diabetes Metab 2021;47:101223
