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Europe follows, driven by guideline-directed medical therapy adoption
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Knerr, S

Emerging evidence suggests that microbial metabolites not only regulate endogenous GLP-1 secretion but may also influence therapeutic response to GLP-1 receptor agonists, raising the prospect of microbiome-guided treatment strategies in obesity and type 2 diabetes

5.11 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin-containing products, including SOLIQUA 100/33

Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial