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After application of 1 M isoprenaline (to stimulate -adrenoceptors) or 1 M serotonin (to stimulate 5-HT4-serotonin receptors) or 1 M histamine (to stimulate H2-histamine receptors) or 10 M fenoldopam (to stimulate D1-dopamine receptors) or 100 nM semaglutide (to stimulate glucagon-like-peptide-1 receptors) or 100 nM gastric inhibitory peptide (to stimulate the gastric inhibitory peptide receptors) additionally applied 1 M muscarine reduced FOC

The number of therapeutic options is limited and are often associated with adverse side effects

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UK-focused guidance.