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Quality control and publication bias of included studies The risk of bias of studies included in the present meta-analysis is presented in Supplemental Figure S1

That said, enthusiasm should be balanced with perspective: Retatrutide remains investigational and is not yet FDA approved Full peer-reviewed Phase 3 data are still pending Safety, tolerability, and long-term outcomes matter as much as efficacy As obesity medicine evolves, the conversation is becoming more sophisticated

If appropriate, your clinician guides the transition, including dose adjustments and side-effect management, to support a smooth change

[DOI] [PubMed] [Google Scholar] [137].Nauck MA, Stewart MW, Perkins C, Jones-Leone A, Yang F, Perry C, Reinhardt RR, Rendell M, Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise, Diabetologia, 59 (2016) 266274

While the relationship between GLP-1 receptor agonists and psychiatric symptoms remains under investigation, some reports have suggested potential mood changes in susceptible individuals