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The effect is not uniform across all patients

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This encompasses support for individuals dealing with overweight or obesity, those with cardiovascular disease risk factors like diabetes or hypertension, kidney disease, eating disorders, and more

Results also vary depending on factors like dosage, lifestyle, and metabolism

The risk of hypoglycemia is increased if the drug is used in combination with sulfonylureas or insulin

Decreased GLP-1 synthesis secondary to reduced proglucagon processing by PC1/3 in enteroendocrine L cells may therefore be the mechanism by which identified PCSK1 SNPs confer an increased risk toward the obesity phenotype