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Larger and longer studies in broader populations are needed to fully understand the safety and efficacy in people with alcohol use disorder, but these initial findings are promising. If future research confirms these results, semaglutide could offer a new way to address alcohol use disorder

While all GLP-1 agonists share some common gastrointestinal effects, the triple agonism of retatrutide introduces glucagon receptor-mediated effects that the others do not produce

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doi: 10.1210/clinem/dgab408 118 MaloneJTrautmannMWilhelmKTaylorKKendallDM