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A patient sat across from me last year six weeks into semaglutide, finally feeling her appetite shift for the first time in years and asked me something I hear in almost every follow-up: "Do I still have to watch what I eat, or does the medication handle that now?" It's a fair question

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GLP-1 secretion in response to dietary lipids In addition to sensing carbohydrates and glucose, L-cells, like other enteroendocrine cells, sense dietary lipids and protein (see next section) through specific cell-surface receptors, which bind metabolites of the dietary lipids and proteins [285] (Figure 4)